Nuclear chromodynamics: non-equilibrium phase transition in the nucleus of a living cell

Nucleus of a living cell houses a cell genome – a polymer called chromatin, which is a functional form of DNA. It is very long, e.g., 2 meters long for every human cell. Nucleus is also an arena of incessant energy-driven activity. Experiments show that chromatin undergoes large scale motions sustained over long times of order seconds. In the talk, after reviewing the phenomenology, I will show how these flows may arise due to a phase transition in which chromatin-driving motors, such as RNA polymerase, form a polar (“ferromagnetic”) order controlled by hydrodynamic interactions. The talk is based on the joint work with I.Eshghi and A.Zidovska.

Lunch served at 12:30.

This seminar will be held in person and on Zoom.

https://harvard.zoom.us/j/96657833341

Password: cmsa