Decoding The Origins of Fluidity in Multicellular Systems

Organisms continually adapt to mechanical forces at the cellular and tissue levels, a process crucial for sustaining vital life functions. In pivotal physiological processes, such as cancer progression and embryonic development, tissues are often poised near solid-like and fluid-like states. My talk will delve into three critical aspects of this phenomenon: (1) utilizing computational models that draw parallels with soft matter physics, we examine shear-induced rigidity and the origins of fluidity in epithelial tissues; (2) exploring the intricate relationship between external mechanical stresses and internal cellular dynamics, unraveling a range of rheological behaviors, such as shear thinning and thickening, which are key for understanding rheological responses in varying physical contexts; and (3) investigating how cellular processes like division and apoptosis influence tissue states, with a specific focus on the emergence of hexatic phases, an intermediate state exhibiting properties of both solids and liquids.

This seminar will be held in person and on Zoom.

https://harvard.zoom.us/j/96657833341

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